The effect of substituted phenothiazines on the mutagenicity of benzo[a]pyrene |
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Authors: | Joseph D. Kittle Jr. Luz M. Calle Paul D. Sullivan |
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Affiliation: | Department of Chemistry, Ohio University Athens, OH 45701, U.S.A. |
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Abstract: | The effect of phenothiazine and 11 of its derivatives on the mutagenicity of benzo[a]pyrene, as measured by the Ames test was investigated. Significant anti-mutagenic activity was detected for 10 phenothiazine derivatives, with the 2-chloro derivative being the most effective inhibitor tested and promazine the only phenothiazine drug tested which has no demonstrable inhibitory activity. It is considered that the anti-mutagenic activity and therefore potentially anticarcinogenic activity of these derivatives should be of interest to epidemiologists. |
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