Enzymatic enantioselective C-C-bond formation in microreactors |
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| Authors: | Koch K van den Berg R J F Nieuwland P J Wijtmans R Schoemaker H E van Hest J C M Rutjes F P J T |
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| Affiliation: | Radboud University Nijmegen, Institute for Molecules and Materials, Toernooiveld 1, NL-6525 ED Nijmegen, The Netherlands. |
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| Abstract: | We have demonstrated that multiple crude enzyme lysates containing a hydroxynitrile lyase can be used for the enantioselective synthesis of cyanohydrins from aldehydes in microchannels. Using a microreactor setup, two important parameters were efficiently screened consuming only minute amounts of reagents. More importantly, results from the continuous flow reaction were fully consistent with results obtained from larger batchwise processes in which a stable emulsion was formed. |
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| Keywords: | microreactors screening enzyme catalysis lyases crude lysates |
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