The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse |
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| Authors: | Ke Zheng Xin Wu Klaus H Kaestner Peijing Jeremy Wang |
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| Affiliation: | (1) Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, 19104 Philadelphia, PA, USA;(2) Department of Genetics, University of Pennsylvania School of Medicine, 19104 Philadelphia, PA, USA |
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| Abstract: | ![]()
Background Life-long production of spermatozoa depends on spermatogonial stem cells. Spermatogonial stem cells exist among the most primitive population of germ cells – undifferentiated spermatogonia. Transplantation experiments have demonstrated the functional heterogeneity of undifferentiated spermatogonia. Although the undifferentiated spermatogonia can be topographically divided into As (single), Apr (paired), and Aal (aligned) spermatogonia, subdivision of this primitive cell population using cytological markers would greatly facilitate characterization of their functions. |
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