Maternal glucocorticoid hormones as a factor mediating the effect of prenatal stress on offspring anxiety |
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Authors: | Ordian N E Pivina S G |
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Affiliation: | Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. neo@infran.ru |
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Abstract: | The plus-maze behavior was studied in offsprings of female rats subjected to immobilization stress on the 15-18 days of pregnancy. Prenatal stress decreased the level of anxiety in males and increased in females. The blockade of the mother's stress-induced glucocorticoid secretion by prior adrenalectomy and subsequent corticosterone injection during immobilization in a low dose (0.3 mg/kg) prevented the behavioral disorders in offsprings. In case of a higher dose of corticosterone (3 mg/kg) injection, the behavior of offsprings was the same as that of offsprings of the intact mothers subjected to immobilization. The results suggest that the stress-induced increase in maternal glucocorticoid level may be the mechanism by which prenatal stress impairs the development of sex differences in rat anxiety behavior. |
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