Essential Role for the Lymphostromal Plasma Membrane Ly-6 Superfamily Molecule Thymic Shared Antigen 1 in Development of the Embryonic Adrenal Gland |
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| Authors: | David J Zammit Stuart P Berzins Jason W Gill Elise S Randle-Barrett Louise Barnett Frank Koentgen Gavin W Lambert Richard P Harvey Richard L Boyd and Brendan J Classon |
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| Institution: | Department of Pathology and Immunology, Monash Medical School, Prahran, Victoria, Australia. david.zammit@med.monash.edu |
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| Abstract: | Thymic shared antigen 1 (TSA-1) is a plasma membrane protein of the Ly-6 superfamily expressed on thymocytes, thymic stromal cells, and other cells of the hematopoietic system. TSA-1 is also expressed in other nonhematopoietic tissues, in particular, embryonic and adult adrenal glands. To address the function of TSA-1, we generated mutant mice in which TSA-1 expression was inactivated by gene targeting. Here we show that deletion of both TSA-1 alleles results in abnormal adrenal gland development and midgestational lethality due to cardiac abnormalities. We also report that TSA-1-deficient adrenal glands have significantly reduced levels of the catecholamines noradrenaline and adrenaline. We conclude that TSA-1 is required for normal embryonic development but that deletion of its expression does not obviously impair lymphoid development. |
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