Synergetic Analgesia of Propentofylline and Electroacupuncture by Interrupting Spinal Glial Function in Rats |
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Authors: | Ling-Li Liang Jia-Le Yang Ning Lü Xi-Yao Gu Yu-Qiu Zhang Zhi-Qi Zhao |
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Institution: | (1) Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Room 1201, Ming-Dao Building, 138 Yi-Xue-Yuan Road, 200032 Shanghai, China; |
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Abstract: | Previous studies indicated that disruption of glial function in the spinal cord enhanced electroacupuncture (EA) analgesia
in arthritic rats, suggesting glia is involved in processing EA analgesia. To probe into the potential value for clinical
practice, the present study was to investigate the effect of propentofylline, a glia inhibitor, on EA analgesia in rats. Mechanical
allodynia induced by tetanic stimulation of sciatic nerve (TSS) was used as a pain model. On day 7 after TSS, EA treatment
induced a significant increase in paw withdrawal threshold to mechanical stimulation. Intrathecal or intraperitoneal injection
of propentofylline relieved TSS-induced mechanical allodynia. The combination of low dosage of propentofylline and EA produced
more potent anti-allodynia than propentofylline or EA alone. Immunohistochemistry exhibited that TSS-induced activation of
microglia and astrocytes was inhibited significantly by propentofylline. These results indicate that propentofylline and EA
induce synergetic analgesia by interrupting spinal glial function. |
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