Synthesis and biological evaluation of thymine nucleosides fused with 3',4'-tetrahydrofuran ring |
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| Authors: | Kim Myong Jung Kim Hea Ok Kim Hee-Doo Kim Joong Hyup Jeong Lak Shin Chun Moon Woo |
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| Affiliation: | College of Pharmacy, Seoul National University, Seoul 151-742, South Korea. |
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| Abstract: | The pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were successfully synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities against HIV-1, HIV-2, EMCV, Cox. B3 and VSV. Thymine analogue (5) and its corresponding 2'-deoxy analogue (6) exhibited high cytotoxicity instead of giving antiviral activities. |
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