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Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Authors:Aldi T Kraja  Chunyu Liu  Jessica L Fetterman  Mariaelisa Graff  Christian Theil Have  Charles Gu  Lisa R Yanek  Mary F Feitosa  Dan E Arking  Daniel I Chasman  Kristin Young  Symen Ligthart  W David Hill  Stefan Weiss  Jian’an Luan  Franco Giulianini  Ruifang Li-Gao  Fernando P Hartwig  Kari E North
Institution:1. Division of Statistical Genomics, Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO 63110, USA;2. Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA;3. Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA;4. Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27516, USA;5. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark;6. Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA;7. GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;8. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;9. Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA;10. Harvard Medical School, Boston, MA 02115, USA;11. Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3015 CE, the Netherlands;12. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK;13. Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald 17475, Germany;14. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, UK;15. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands;16. Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas 96020-220, Brazil;17. MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol BS8 2BN, UK;18. Institute for Translational Genomics and Population Sciences, LABioMed and Department of Pediatrics, at Harbor-UCLA Medical Center, Torrance, CA 90502, USA;19. Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan;20. Department of Social Work, Tunghai University, Taichung 407, Taiwan;21. Department of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60612, USA;22. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA;23. Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA;24. School of Medicine, Division of Endocrinology, Diabetes and Nutrition, and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA;25. Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO 63110, USA;26. Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA;27. Center for Diabetes Research, Wake Forest School of Medicine, Cincinnati, OH 45206, USA;28. Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA;29. The Danish Aging Research Center, University of Southern Denmark, Odense 5000, Denmark;30. Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, the Netherlands;31. Samford University McWhorter School of Pharmacy, Birmingham, Alabama, Translational Genomics Research Institute (TGen), Phoenix, AZ 35229, USA;32. Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands;33. Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA;34. Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK;35. Department of Hygiene and Epidemiology, University of Ioannina, Ioannina 45110, Greece;36. Steno Diabetes Center Copenhagen, Copenhagen 2820, Denmark;37. Department of Biostatistics, University of Washington, Seattle, WA 98195, USA;38. Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK;39. Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA;40. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Centre for Genomic and Experimental Medicine, Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, UK;41. Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA;42. Department of Genetic Medicine, Weill Cornell Medicine, PO Box 24144, Doha, Qatar;43. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA;44. Biomedical and Translational Informatics, Geisinger Health, Danville, PA 17822, USA;45. Department of Ophthalmology, Taichung Veterans General Hospital, Taichung 407, Taiwan;46. Genomics & Pathology Services, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA;47. GeneSTAR Research Program, Divisions of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;48. Taub Institute for Research on Alzheimer disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA;49. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany;50. University of Minnesota School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN 55454, USA;51. Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA;52. Department of Epidemiology & Population Health, Albert Einstein School of Medicine, Bronx, NY 10461, USA;53. Department of Endocrinology, Diabetes and Metabolism, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark;54. The Danish Diabetes Academy, 5000 Odense, Denmark;55. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA;56. Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK;57. Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany;58. Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark;59. Computer Science and Networking, Wentworth Institute of Technology, Boston, MA 02115, USA;60. Genome Technology Access Center, Washington University School of Medicine, St Louis, MO 63110, USA;61. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;62. Department of Public Health, Section of Epidemiology, Aarhus University, Denmark, Danish Diabetes Academy, Odense University Hospital, 5000 Odense, Denmark;63. Division of Nephrology and Hypertension, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55902, USA;64. Department of Health Science and Technology, Aalborg University Hospital, Aalborg 9220, Denmark;65. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan;66. Institute of Medical Technology, National Chung-Hsing University, Taichung 402, Taiwan;67. School of Medicine, National Defense Medical Center, Taipei 114, Taiwan;68. School of Medicine, National Yang-Ming University, Taipei 112, Taiwan;69. Institute of Social and Preventive Medicine (ISPM), University of Bern, 3012 Bern, Switzerland;70. Department of Medicine, Geriatrics Section, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA;71. Research Unit for Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark;72. Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA;73. Department of Clinical Experimental Research, Rigshospitalet, Copenhagen 2200, Denmark;74. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark;75. The Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen 2000, Denmark;76. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA;77. Research Centre for Prevention and Health, Glostrup Hospital, Glostrup 2600, Denmark;78. Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen 1014, Denmark;79. Faculty of Medicine, Aalborg University, Aalborg 9100, Denmark;80. Novo Nordisk Foundation Center for Basic Metabolic Research (Section of Metabolic Genetics) and Department of Public Health (Section on Epidemiology), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200N, Denmark;81. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA;82. Department of Internal Medicine, Section of Endocrinology, Vejle Lillebaelt Hospital, 7100 Vejle, Denmark;83. Center for Complex Disease Genomics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA;84. Department of Clinical Biochemistry, Vejle Hospital, 7100 Vejle, Denmark;85. Institute of Regional Health Research, University of Southern Denmark, 5000 Odense C, Denmark;86. Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte & Naestved 2820, Denmark;87. Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark;88. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA;89. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA;90. Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK;91. University of Kentucky, College of Public Health, Lexington, KY 40508, USA;92. MRC Human Genetics Unit, University of Edinburgh, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK;93. Department of Public Health and Primary Care, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands;94. The Framingham Heart Study, Framingham, MA, USA; The Population Sciences Branch, NHLBI/NIH, Bethesda, MD 20892, USA;95. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;96. Genetics of Obesity and Related Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;97. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;98. King’s College London, Department of Diabetes, School of Life Course, Faculty of Life Sciences and Medicine, London SE1 1NN, UK;99. Division of General Internal Medicine, Massachusetts General Hospital, Boston 02114, MA, USA;100. Program in Medical and Population Genetics, Broad Institute, Boston, MA 02142, USA
Abstract:
Keywords:mitochondria  mtDNA  MT-nDNA candidate genes  BMI  waist-to-hip ratio  glucose  insulin  HOMA-B  HOMA-IR  HbA1c
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