Monoamine and diamine oxidase activities in uremic rats |
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| Authors: | Marian Wang Chick-Fai Tam Marian E. Swendseid Joel D. Kopple |
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| Affiliation: | 1. Schools of Public Health and Medicine, University of California, Los Angeles, USA;2. Medical and Research Services, Veterans Administration, Wadsworth Hospital Center, Los Angeles, California 90024, USA |
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| Abstract: | The activities of monoamine and diamine oxidases in various organs and tissues and the amine levels in plasma and urine were determined in chronically uremic and pair-fed control rats. Plasma amine levels were elevated in uremic animals while the urinary excretion of amines was decreased. In uremic as compared to control animals, monomaine oxidase activity was decreased in kidney and muscle, increased in heart and plasma and not altered in liver and cerebrum. Diamine oxidase activity in uremic rats was decreased in kidney, increased in plasma and unchanged in liver and muscle. These alterations of amine oxidase activities in renal failure may affect the metabolism of many amines and thus contribute to the pathogenesis of the uremic syndrome. |
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