Alkaloids of Uncaria attenuata,U. orientalis and U. Canescens |
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Authors: | J. David Phillipson Sarah R. Hemingway |
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Affiliation: | Department of Pharmacognosy, The School of Pharmacy, (University of London), 29–39, Brunswick Square, London WC1N 1AX, England |
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Abstract: | 3-Iso-19-epi-ajmalicine, epiallo-corynantheine and dihydrocorynantheine pseudoindoxyl, not previously known as natural products, have been isolated from samples of U. attenuata. Akuammigine, dihydrocorynantheine, hirsutine, hirsuteine, mitraphylline, speciophylline, uncarines A and B, isorhynchophylline rhynchophylline, isocorynoxeine, corynoxeine, corynoxine B, rotundifoline, speciofoline, two yohimbine isomers, a yohimbine oxindole and an unidentified indole alkaloid (M+, m/e 347) have been obtained from samples of the same species. 3-Iso-ajmalicine, harmane, isopteropodine, pteropodine, uncarine F, speciophylline, isomitraphylline, mitraphylline and N-oxides of these six oxindole alkaloids have been isolated from samples of U. orientalis. Several samples of U. canescens have yielded harmane while one sample contained the four pteropodine isomers. The variation in the alkaloid content of these three species is discussed. |
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Keywords: | Rubiaceae heteroyohimbine, oxindole alkaloids dihydrocorynantheine pseudoindoxyl yohimbine isomers yohimbine oxindole. |
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