Plasma catecholamines: Arterial-venous differences and the influence of body temperature |
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Authors: | Michael F. Roizen Virginia Weise Jonathan Moss Irwin J. Kopin |
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Affiliation: | Laboratory of Clinical Science National Institute of Mental Health Bethesda, Maryland 20014 USA |
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Abstract: | Using sensitive radio-enzymatic assays, levels of plasma total catecholamines and norepinephrine in rats change dramatically with changes in body temperature. The decrease in plasma catecholamines induced by warming the animal is reflected in an apparent arterio-venous difference when arterial blood is obtained at room temperature and tail sampling is aided by heat induced vasodilation. Combined blockade of extraneuronal and neuronal uptake reduces this arterio-venous difference. Blood samples obtained from the decapitated trunk of the rat contain similar levels of plasma catecholamines as those obtained from indwelling carotid catheters. Blood levels of dopamine-betahydroxylase were similar whether obtained by venous sampling during heat-induced vasodilation, decapitation or indwelling arterial cannula. |
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