Metabolism of 24-dihydrolanosterol in Ochromonas malhamensis and Chlorella ellipsoidea |
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| Authors: | Larry B. Tsai John H. Adler Glenn W. Patterson |
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| Affiliation: | Department of Botany, University of Maryland, College Park, Maryland 20742, U.S.A. |
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| Abstract: | 24-Dihydrolanosterol-[2-3H] was converted to cholesterol in Chlorella ellipsoidea but ergost-5-enol, poriferasterol, clionasterol were not labelled. The absence of the necessary 24(25) double bond precursor eliminates the possibility of C28 and C29 sterol synthesis. However, it was confirmed that 24-dihydrolanosterol was metabolized by Ochromonas malhamensis to give cholesterol, brassicasterol, and poriferasterol. |
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| Keywords: | sterol biosynthesis 24-dihydrolanosterol metabolism |
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