Mutations to azaguanine resistance induced in cultured diploid human fibroblasts by the carcinogen, N-acetoxy-2-Acetylaminofluorene |
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Authors: | Veronica M. Maher James E. Wessel |
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Affiliation: | Division of Biological Sciences, Michigan Cancer Foundation, Detroit, Mich. 48201 U.S.A. |
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Abstract: | The ability of the carcinogen, N-acetoxy-2-acetylaminofluorene (N-AcO-AAF), to induce mutations to azaguanine resistance in diploid human cells was quantitatively investigated and shown to be dose-dependent. The 8-azaguanine (AG) resistance was shown to be heritable in the absence of mutagen or selective agent and the cells of the mutant clones were shown to retain normal sensitivity to N-AcO-AAF. |
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Keywords: | AG 8-azaguanine HG-PRT hypoxanthine(guanine) phosphoribosyltransferase (EC 2.4.2.8)) N-AcO-AAF |
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