Ameliorative effects of resveratrol on liver injury in streptozotocin‐induced diabetic rats |
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| Authors: | Nasereddine Hamadi Ahmed Mansour Memy H Hassan Fatima Khalifi‐Touhami Osama Badary |
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| Institution: | 1. Department of Biology, Mentouri Mahmoud University, Constantine, Algeria;2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al‐Azhar University, Cairo, Egypt;3. Department of Pharmacy, Faculty of Medical Rehabilitation Sciences, Taibah University, Kingdom of Saudi Arabia;4. Department of Clinical Pharmacy, Faculty of Pharmacy, Ain‐Shams University, Cairo, Egypt |
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| Abstract: | The objective of this study was to investigate the ameliorative property and potential mechanism of resveratrol (RVT) in a dose of 10 mg/kg for 15 consecutive days against liver injury in streptozotocin‐induced diabetic rats. Diabetic rats significantly (P < 0.05) exhibited liver injury manifested by increased aspartylaminotransferase, alanine aminotransferase, and bilirubin; disturbed liver weight to body weight; and confirmed by hematoxylin and eosin staining. Liver from diabetic rats exhibited significant increase in malondialdehyde level and significant decrease in reduced glutathione, glutathione‐S‐transferase, quinone reductase, catalase, and superoxide dismutase. Diabetic rats showed significant disturbance in serum lipid profile. Treatment with RVT significantly (P < 0.05) abrogated diabetes‐induced perturbation in these parameters and liver histology. These data suggest that RVT treatment is associated with promising hepatoprotective effect against diabetes‐induced liver damage via reduction of serum glucose level and oxidative damage and improving serum lipid profile. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:384–392, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21432 |
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| Keywords: | Diabetes Mellitus Oxidative Stress Resveratrol Streptozotocin |
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