The identification of 24-methylene-24,25-dihydrolanosterol and other possible ergosterol precursors in Phycomyces blakesleeanus and Agaricus campestris |
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| Authors: | Geoffrey Goulston E Ian Mercer L John Goad |
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| Institution: | Department of Biochemistry and Agricultural Biochemistry, University College of Wales. Aberystwyth, SY23 3DD U.K.;Department of Biochemistry, University of Liverpool, P.O. Box 147. Liverpool, L69 3BX U.K. |
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| Abstract: | The following sterols have been isolated from the fungi, Phycomyces blakesleeanus and Agaricus campestris: ergosterol, lanosterol, 24-methylene-24,25-dihydrolanosterol and episterol. 4,4-Dimethyl-5α-ergosta-8.24(28)-dien-3β-ol and 4α-methyl-5α-ergosta-8,24(28)-dien-3β-ol have been tentatively identified. Evidence for the incorporation of label from l-methionine-methyl-14C] into some of these sterols in P. blakesleeanus has been obtained. The significance of these sterols in ergosterol biosynthesis is discussed. |
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| Keywords: | Mucoraceae Agaricaceae mushroom biosynthesis sterols ergosterol lanosterol 24-methylene-24 25-dihydrolanosterol |
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