Cysteine sulfinic acid decarboxylase in rat brain: Effect of vitamin B6 deficiency on soluble and particulate components |
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Authors: | David K. Rassin John A. Sturman |
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Affiliation: | Department of Pediatric Research Institute for Basic Research in Mental Retardation 1050 Forest Hill Road Staten Island, New York 10314, USA |
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Abstract: | Cysteine sulfinic acid decarboxylase activity is not affected when measured in the presence of pyridoxal phosphate in the brains of vitamin B6-deficient rats. Activity of this enzyme was not detectable in the brains of vitamin B6-deficient animals when assayed in the absence of pyridoxal phosphate. The activity of cysteine sulfinic acid decarboxylase in crude particulate and soluble fractions of rat brain reflects the distribution of the enzyme and the distribution of endogenous B6 vitamers when assayed in the presence and absence of vitamin B6. This study indicates that virtually no taurine is synthesized by any component of brain when the animal is subjected to a deficiency of vitamin B6. |
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