Alcaloides d'Alstonia lanceolifera |
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| Authors: | Guy Lewin Nicole Kunesch Adrien Cave Thierry Sevenet Jacques Poisson |
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| Affiliation: | 1. Centre d''Etudes Pharmaceutiques, Laboratoire de Chimie des Substances Thérapeutiques Naturelles, Equipe de Recherche Associée au C.N.R.S. no. 317 Av. J. B. Clément 92290, Châtenay-Malabry France;2. Equipe de Recherche de Biophysique C.N.R.S., U.S.T.L., 34060, Montpellier France;3. Institut de Chimie des Substances Naturelles du C.N.R.S. 91190, Gif sur Yvette, France |
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| Abstract: | From the aerial parts of Alstonia lanceolifera six alkaloids were isolated and identified: O-trimethoxycinnamoylvincamajine, O-trimethoxy-cinnamoyl-10-methoxyvincamajine, O-trimethoxycinnamoyl-10-hydroxyvincamajine, O-trimethoxybenzoylhydroxyvincamajine, 10-methoxyvincamajine, N(a)-methyl-10-methoxyakuammidine. These alkaloids are new compounds, except for the first. The position of aromatic substituents was determined by study of the Nuclear Overhauser Effect (N.O.E.) in the NMR spectra. |
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| Keywords: | Apocynaceae indole alkaloids vincamajine derivatives. |
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