Xanthones of Swertia bimaculata |
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Authors: | Shibnath Ghosal Prem V Sharma Ratan K Chaudhuri |
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Institution: | Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Banaras Hindu University, Varanasi-5, India |
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Abstract: | The whole plant of Swertia bimaculata Hf. & T. has been shown to contain four tetra-and five penta-oxygenated xanthones, three of which are previously unreported in nature. The xanthones are broadly based on 1,3,5- and 1,3,7-oxygenated systems with added oxygen functions at C2, C4 and/or C8 positions and represent a number of methoxylated patterns. In addition, three xanthones have been found to be present in a bound form, the sugar moiety containing glucose and glucuronic acid. This is the first demonstration of the occurrence of xanthones and xanthone disaccharides in a Swertia species which are common to both Swertia and Frasera species. The results are thus of considerable phylogenetic significance. |
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Keywords: | Gentianaceae tetra- and penta-oxygenated xanthones 1 3 5-trimethoxy-8-hydroxyxanthone 1 4-dihydroxy-2 3 7-trimethoxyxanthone 1 3-dihydroxy-4 5 8-trimethoxyxanthone |
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