Triterpenes and lignans from the leaves of Styrax tonkinensis |
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| Institution: | 1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, JS, 210009, China;2. School of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China;3. Tang Center of Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL, 60637, USA;1. Central Analítica - Centro de Apoio Multidisciplinar (CAM), Universidade Federal do Amazonas, 69077-000, Manaus, AM, Brazil;2. Centro de Biotecnologia da Amazônia, 69075-351, Manaus, AM, Brazil;3. Departamento de Química, Universidade Federal do Amazonas, 69077-000, Manaus, AM, Brazil;1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, 02115, MA, USA;2. Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany;3. Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany;4. Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia;1. Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, #1 Weigang, Nanjing, 210095, Jiangsu Province, PR China;2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, #4655 Daxue Road, Jinan, 250355, Shandong Province, PR China;3. MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, PR China;4. Jiangsu Vocational College of Agricultural and Forestry, Zhenjiang, 212400, Jiangsu Province, PR China;1. State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China;2. National Institutes for Food and Drug Control, Beijing, 102629, China;3. Guangzhou Welman New Drug R&D CO., LTD, Guangzhou, 510620, China;4. School of Chinese Medicine, Hong Kong Baptist University, Hongkong, China;1. School of Pharmacy, Zunyi Medical University, Zunyi 563000, China;2. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China;3. College of Life Science, Sichuan University, Chengdu 610064, China;1. Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai, China;2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China |
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| Abstract: | Two triterpenes (1 and 2) and eight lignans (3–10) were isolated from the ethyl acetate-soluble fraction of the leaves of Styrax tonkinensis (Pierre) Craib ex Hartw (Styracaceae). Their structures were established as ursolic acid (1), pomolic acid (2), 3,3′-bis(3,4-dihydro-6-methoxy-2H-1-benzopyran) (3), rac-(8α,8′β)-4,4′-dihydroxy-3,3′-dimethoxylignan-9,9′-diyldiacetate (4), (-)-secoisolariciresinol (5), (+)-pinoresinol (6), 4,4′-dihydroxy-3,3′-dimethoxy-9-ethoxy-9,9′-epoxylignan (7), (2S,3R, 4R)-4-1-ethoxy-1-(4-hydroxy-3-methoxy)phenyl]methyl-2-(4-hydroxy-3-methoxy)phenyl-3-hydroxymethyl-tetrahydrofuran (8), (-)-neo-olivil-(9-O-9″)-seco-isolariciresinol (9) and isolariciresinol (10) based on MS, 1H-and 13C-NMR spectral data. All these compounds (1–10) were firstly isolated from this plant, and compounds 2–5 and 7–9 were reported from the Styrax genus for the first time. Furthermore, the chemotaxonomic significance of the isolated compounds was discussed. |
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| Keywords: | Triterpenes Lignans |
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