Steroids and anthraquinones from the deep-sea-derived fungus Aspergillus nidulans MCCC 3A00050 |
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| Institution: | 1. Key Laboratory of Marine Biogenetic Resources, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005, China;2. Yanjing Medical College, Capital Medical University, 4 Dadong Road, Beijing, 101300, China;1. College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou, 450002, China;2. Technology Center, China Tobacco Henan Industrial Co., Ltd, Zhengzhou, 450000, China;1. School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo ku, Kumamoto, 862-0973, Japan;2. Program for Leading Graduate Schools, Health Life Science: Interdisciplinary and Glocal Oriented (HIGO) Program, Kumamoto University, Kumamoto, Japan;1. Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon;2. Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;3. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan;4. Pharmaceutical Research Center, PCSIR Laboratories Karachi Complex, Karachi, 75280, Pakistan;5. Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon;1. State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, 100091, China;2. Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, SE-901 87, Umeå, Sweden;1. Université de Corse - CNRS, UMR 6134 SPE, Equipe Chimie et Biomasse, Route des Sanguinaires, 20000, Ajaccio, France;2. Neuchâtel Platform of Analytical Chemistry, University of Neuchâtel, Avenue de Bellevaux 51, 2000, Neuchâtel, Switzerland;1. Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM, 43400, Selangor Darul Ehsan, Malaysia;2. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, 38677, USA;3. Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, 38677, USA;4. Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, UPM, 43400, Selangor Darul Ehsan, Malaysia;5. Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM, 43400, Selangor Darul Ehsan, Malaysia |
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| Abstract: | Aspergillus nidulans MCCC 3A00050 was isolated from a deep-sea sediment sample of the western Pacific Ocean. A systematic investigation on its chemical constituents led to the isolation of 19 compounds, including 13 steroids (1–13), four anthraquinones (14–17), one phenolics (18), and one chromanone (19). For the first time, three diosgenins (1–3) were isolated from fungi, three ergosterols (4–6) from the genus of Aspergillus, while other 11 miscellaneous compounds (7–11 and 14–19) from the species of Aspergillus nidulans. The isolation of diosgenins (1–3) and ergosterols (4–6) might be used as chemotaxonomic markers for the genus of Aspergillus and the species of Aspergillus nidulans, respectively. |
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| Keywords: | Deep-sea Steroids Anthraquinones |
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