Natural products from the medicinal plant Duguetia staudtii (Annonaceae) |
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| Institution: | 1. Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon;2. Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;3. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan;4. Pharmaceutical Research Center, PCSIR Laboratories Karachi Complex, Karachi, 75280, Pakistan;5. Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon;1. School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo ku, Kumamoto, 862-0973, Japan;2. Program for Leading Graduate Schools, Health Life Science: Interdisciplinary and Glocal Oriented (HIGO) Program, Kumamoto University, Kumamoto, Japan;1. Key Laboratory of Marine Biogenetic Resources, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005, China;2. Yanjing Medical College, Capital Medical University, 4 Dadong Road, Beijing, 101300, China;1. Université de Corse - CNRS, UMR 6134 SPE, Equipe Chimie et Biomasse, Route des Sanguinaires, 20000, Ajaccio, France;2. Neuchâtel Platform of Analytical Chemistry, University of Neuchâtel, Avenue de Bellevaux 51, 2000, Neuchâtel, Switzerland;1. Department of Plant Protection, University of Life Sciences in Lublin, Leszczyńskiego 7, 20-069, Lublin, Poland;2. Department of Biochemistry and Molecular Biology, Siedlce University of Natural Sciences and Humanities, Prusa 12, 08-110, Siedlce, Poland;3. Department of Molecular Biotechnology, Faculty of Biotechnology, University of Rzeszów, Pigonia 1, 35-310, Rzeszów, Poland;1. State Key Laboratory of Innovative Drugs and High Efficiency Energy Saving and Consumption Reduction Pharmaceutical Equipment, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China;2. College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, 473061, China |
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| Abstract: | The phytochemical investigation of the ethyl acetate soluble fraction of Duguetia staudtii stem bark led to the isolation of eight compounds consisting into a new bisnorlignan named pachypolignan (1), a known bisnorlignan (2), four flavonoids (3–6), one alkaloid (7), and one triterpenoid (8). The structures of all the compounds were established with help of spectral data including IR, UV, MS, 1D- and 2D-NMR spectroscopic data, as well as by comparison with previously-reported data in literature. The anti-inflammatory and urease inhibitory activities of the isolated compounds were assessed. Furthermore, the chemotaxonomic significance of these compounds was discussed. |
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| Keywords: | Annonaceae Bisnorlignan Chemotaxonomy |
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