Reduced expression of CRH receptor type 1 in upper segment human myometrium during labour |
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| Authors: | Binhai Cong Lanmei Zhang Lu Gao and Xin Ni |
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| Institution: | (1) Department of Physiology, Second Military Medical University, Shanghai, 200433, PR China;(2) Department of Gynecology and Obstetric, Navy General Hospital, Beijing, 10037, PR China |
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| Abstract: | Background Corticotropin-releasing hormone (CRH) and CRH-related peptide are shown to modulate uterine contractility through two CRH
receptor subtype, CRH-R1 and CRH-R2 during pregnancy. Through different signaling pathways, CRH-R1 maintains myometrial quiescence
whereas CRH-R2 promotes smooth muscle contractility. We hypothesized that the expression of CRH receptors in myometrium might
be changed during pregnancy and labour. |
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