Novel deprotection method of Fmoc group under neutral hydrogenation conditions |
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| Authors: | Tomohiro Maegawa Yuta Fujiwara Takashi Ikawa Hideo Hisashi Yasunari Monguchi Hironao Sajiki |
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| Institution: | (1) Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan; |
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| Abstract: | Novel deprotection method of the Fmoc (9-flurorenylmethoxycarbonyl) protective group under Pd/C-catalyzed hydrogenation conditions
at room temperature was developed. The addition of CH3CN accelerated the deprotection of the Fmoc group, and also the application of H2 pressure (3 atm) shows notable rate enhancement. |
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