Arsenic transport by zebrafish aquaglyceroporins |
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| Authors: | Mohamad Hamdi Marco A Sanchez Lauren C Beene Qianyong Liu Scott M Landfear Barry P Rosen and Zijuan Liu |
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| Institution: | (1) Dept. of Biological Sciences, Oakland University, Rochester, MI 48309, USA;(2) Dept. of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, USA;(3) Oregon Hearing Research Center, Oregon Health & Science University, Portland, OR, USA;(4) College of Medicine, Florida International University, Miami, FL, USA |
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| Abstract: | Background Arsenic is one of the most ubiquitous toxins and endangers the health of tens of millions of humans worldwide. It is a mainly
a water-borne contaminant. Inorganic trivalent arsenic (AsIII) is one of the major species that exists environmentally. The transport of AsIII has been studied in microbes, plants and mammals. Members of the aquaglyceroporin family have been shown to actively conduct
AsIII and its organic metabolite, monomethylarsenite (MAsIII). However, the transport of AsIII and MAsIII in in any fish species has not been characterized. |
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