Developmental changes in the fatty acids of synaptic membrane phospholipids: Effect of protein malnutrition |
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Authors: | Robert Hitzemann |
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Institution: | (1) Laboratory of Psychobiology Departments of Psychiatry and Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Bethesda Avenue, 45267 Cincinnati, Ohio |
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Abstract: | The acyl-linked fatty acid composition of the major phospholipid species in rat cortical synaptic membranes was determined at various stages of development. For most species there was a decrease during development in the short chain saturated fatty acids, 14 0 and 16 0, an increase in 18 0 and 22 6 (n-3) and an increase in the ratio of 22 6 (n-3)/22 5 (n-6). Pups were protein deprived by feeding the dams a 12% casein diet as compared to the 24% casein control diet. Protein malnutrition markedly affected the composition of acyl-linked fatty acids in the synaptic membranes. The increases in the ratio of 22 6 (n-3)/22 5 (n-6) fatty acids were especially compromised.Abbreviations used (PC)
Phosphatidylcholine
- (PE)
phosphatidylethanolamine
- (EP)
ethanolamine plasmalogen
- (PS)
phosphatidylserine
- (PI)
phosphatidylinositol
- (SP)
sphingomyelin
- (t.l.c.)
thin layer chromatography
- (BHT)
butylated-hydroxytoluene |
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Keywords: | |
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