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Effects of marine organisms extracts on microtubule integrity and cell cycle progression in cultured cells |
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| Authors: | MP Prado RGS Berlinck MA Sanchez E Hajdu GM Machado-Santelli |
| Institution: | a Departamento de Histologia e Embriologia, Instituto de Ciências Biológicas I, Universidade de São Paulo, Av. Lineu Prestes CP1524, CEP 05508-900, São Paulo, SP, Brasil b Instituto de Química de São Carlos, Universidade de São Paulo, CP, 780, CEP 13560-970, São Carlos, SP, Brasil c Departamento de Invertebrados, Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista, s/n, CEP 20940-040, Rio de Janeiro, RJ, Brasil d Departamento de Zoologia, Setor de Ciências Biológicas, Universidade Federal do Paraná, Centro Politécnico, Jardim das Américas s/n, CP 19020, CEP 81531-990 Curitiba, Paraná, Brasil |
| Abstract: | Marine organisms have been reported to be a rich source of biologically active compounds, but when compared with plants, their use is much more restrict in popular medicine. Among marine animals, sponges and ascidians are two of the most prominent sources of new compounds with cytotoxic potential. In this study, we tested 40 extracts of marine sponges and ascidians from southeastern Brazilian coast aiming to evaluate their anti-proliferative effects on cultured cells. The extracts of Amorphinopsis sp., Arenosclera brasilensis, Cystodytes dellechiajei, Cliona aff. celata, Didemnum sp., Hadromerida and Scopalina ruetzleri showed an IC50≤30 μg/mL and produce strong effects on microtubules organization and on the cell cycle progression. |
| Keywords: | Brazil Cell cycle progression Cytotoxicity Marine organisms Extracts Microtubules |
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