| 细胞自噬中关键蛋白乙酰化修饰与相关疾病诊治的研究进展 |
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| 引用本文： | 金露琪,闫春兰,刘威岗,万群,丁世萍. 细胞自噬中关键蛋白乙酰化修饰与相关疾病诊治的研究进展[J]. 中国细胞生物学学报, 2021, 0(1): 186-193 |
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| 作者姓名： | 金露琪 闫春兰 刘威岗 万群 丁世萍 |
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| 作者单位： | 浙江大学医学院细胞生物学研究所;浙江大学医学院神经科学研究所;浙江大学医学院附属第一医院 |
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| 基金项目： | 浙江省基础公益研究基金(批准号:LGF19260013);浙江省自然科学基金(批准号:LR12H26001)资助的课题。 |
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| 摘 要： | 自噬是一种在进化上保守的溶酶体依赖的降解途径.近十多年来,自噬过程的分子机制研究得到了长足的发展.自噬过程中关键蛋白复合物的乙酰化修饰发挥了十分重要的作用.为此,该文阐述了细胞自噬过程中主要蛋白复合物的乙酰化修饰作用进展,并对蛋白质乙酰化修饰与肿瘤、神经退行性疾病等的关系作一总结.总之,自噬过程中蛋白乙酰化修饰已经成为...
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| 关 键 词： | 翻译后修饰 蛋白质乙酰化修饰 自噬 乙酰基转移酶 去乙酰化酶 |
Research Progresses of Acetylation of Key Protein in Cell Autophagy and the Treatment of Related Diseases |
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| JIN Luqi,YAN Chunlan,LIU Weigang,WAN Qun,DING Shiping. Research Progresses of Acetylation of Key Protein in Cell Autophagy and the Treatment of Related Diseases[J]. , 2021, 0(1): 186-193 |
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| Authors: | JIN Luqi YAN Chunlan LIU Weigang WAN Qun DING Shiping |
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| Affiliation: | (Institute of Cell Biology,Zhejiang University School of Medicine,Hangzhou 310058,China;Institute of Neuroscience,Zhejiang University School of Medicine,Hangzhou 310058,China;the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China) |
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| Abstract: | Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation.In the past decade,the molecular mechanisms underlying autophagy have been extensively studied.Importantly,the key role of acetylated autophagy complexes has been identified and elucidated.This review systematically summarizes the current knowledge of acetylation of the key autophagy complexes,the function of these modifications,and their therapeutic functional implications in cancer and neurodegenerative diseases.In conclusion,acetylation has become the hot talk of autophagy researches.Understanding the acetylation of the autophagy machinery offers a unique window for the control of autophagy-related diseases. |
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| Keywords: | post-translational modification protein acetylation autophagy acetylase deacetylase |
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