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In vitro stimulation of spleen cell cultures by poly I: poly C and levamisole |
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| Authors: | W A Woods M J Siegel M A Chirigos |
| Institution: | Viral Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 U.S.A.;Frederick Cancer Research Center, Frederick, Maryland 21701 U.S.A.;Viral Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 U.S.A. |
| Abstract: | Poly I: poly C and levamisole (LMS) were shown to stimulate DNA synthesis by spleen cell suspension cultures. Poly I: poly C was more effective than LMS at concentrations above 1 μg/ml; both agents were weakly stimulatory at concentrations 0.1–1.0 μg/ml. Levamisole augmented the DNA synthetic response to a supraoptimal concentration of phytohemagglutinin. |
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