Changes in the levels of catecholamines, hexokinase and glucose 6-phosphate dehydrogenase in red cell aging |
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Authors: | M Nehal M Azam N Z Baquer |
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Institution: | School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. |
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Abstract: | The activity of the enzymes hexokinase and glucose 6-phosphate dehydrogenase and the level of catecholamines were measured in isolated rat Red Blood Cells (RBC) during cellular aging. The results clearly showed a linear decline in the two enzyme profiles with corresponding increase in age of RBC. A decrease of 75-85% in the activities were found in the oldest cell fractions as compared to the youngest. The levels of glycosylated haemoglobin and catecholamines were found to increase with aging. A correlation can probably be established between the enzyme activities, the levels of glycosylated haemoglobulin and catecholamines during aging. |
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