Dynamics of the retrograde transport of horseradish peroxidase in the trigeminal nerve during burn keratitis

The dynamics of trigeminal neuron labelling with horseradish peroxidase (HRP) has been studied in rats during thermal burn keratitis. HRP application on the cornea after burn prolongs the time of its appearance in the perikarya cells of trigeminal ganglia, decreasing the number of labelled neurons. A more marked inflammation led to the decline in the number of nervous cells containing HRP. The decreased number of labelled HRP cells was recorded during the regeneration phase. This difference in the dynamics of neuron labelling in trigeminal ganglia was associated with the damaging effect of high temperature and inflammation on HRP uptake and transportation.