Growth effects of tin compounds in rats maintained in a trace element-controlled environment |
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| Authors: | K Schwarz D B Milne E Vinyard |
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| Affiliation: | 1. Laboratory of Experimental Metabolic Diseases, Veterans Administration Hospital, Long Beach, California 90801, USA;2. Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California 90024, USA;1. Institute of Coordination Bond Metrology and Engineering, School of Materials Science and Engineering, China Jiliang University, 310018 China;2. Engineering Research Center for Nanophotonics and Advanced Instrument, Ministry of Education, Department of Physics, East China Normal University, 200062 China;3. College of Modem Science and Technology, China Jiliang University, 310018 China |
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| Abstract: | In rats maintained on purified amino acid diets in trace element-controlled isolators, supplements of tin caused a significant growth effect. The diets were adequate in all known nutritional factors, including trace elements thus far identified as necessary, but they were composed of ingredients which kept trace element impurities at a minimum. Trimethyl tin hydroxide, dibutyl tin maleate, stannic sulfate, and potassium stannate enhanced growth at dose levels supplying 100 μg% (1 ppm) of tin to the diet. When supplied in form of stannic sulfate, 50, 100, and 200 μg% of tin increased growth by 24, 53, and 59%, respectively. These levels of tin are similar to those normally present in foods, feeds, and tissues. The results suggest that tin is a hitherto unrecognized essential trace element. |
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