Serotonin-sensitive aryl acylamidase in rat brain |
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Authors: | D Fujimoto |
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Affiliation: | Hamamatsu University School of Medicine Hamamatsu, Japan |
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Abstract: | Aryl acylamidase (E.C.3.5.1.13) was extracted from rat brain. The enzyme activity was inhibited by low concentrations of serotonin. The inhibition was non-competitive type and Ki value was about 3 × 10?5M. Tryptamine inhibited the enzyme to a lesser extent. Other amines such as noradrenaline, tyramine and histamine did not affect the enzyme reaction. In contrast, aryl acylamidase from rat liver was insensitive to serotonin. |
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