Effect of pH-sodium lauryl sulfate combination on solubilization of PG-300995 (an Anti-HIV agent): A technical note |
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| Authors: | Akash Jain Yingqing Ran Samuel H Yalkowsky |
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| Institution: | (1) Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona, 1703 East Mabel Street, Room 441, 85721 Tucson, AZ |
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| Abstract: | Conclusion Solubilization of PG-300995 has been achieved using SLS at low pH. However, at a pH where both the solute and surfactant are
ionized, desolubilization can occur owing to the formation of an insoluble estolate salt. This salt can be solubilized by
higher concentrations of SLS. |
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| Keywords: | solubilization desolubilization pH surfactant micellization SLS |
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