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Indanylacetic acids as PPAR-delta activator insulin sensitizers
Authors:Wickens Philip  Zhang Chengzhi  Ma Xin  Zhao Qian  Amatruda John  Bullock William  Burns Michael  Cantin Louis-David  Chuang Chih-Yuan  Claus Thomas  Dai Miao  Dela Cruz Fernando  Dickson David  Ehrgott Frederick J  Fan Dongping  Heald Sarah  Hentemann Martin  Iwuagwu Christiana I  Johnson Jeffrey S  Kumarasinghe Ellalahewage  Ladner David  Lavoie Rico  Liang Sidney  Livingston James N  Lowe Derek  Magnuson Steve  Mannelly Gretchen  Mugge Ingo  Ogutu Herbert  Pleasic-Williams Susan  Schoenleber Robert W  Shapiro Jeff  Shelekhin Tatiana  Sweet Laurel  Town Christopher  Tsutsumi Manami
Affiliation:Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. pcwickens@hotmail.com
Abstract:A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-alpha and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-alpha.
Keywords:
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