Estradiol increases IRS-1 gene expression and insulin signaling in breast cancer cells. |
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Authors: | L Mauro M Salerno M L Panno D Bellizzi D Sisci A Miglietta E Surmacz S Andò |
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Affiliation: | Department of Cellular Biology, University of Calabria, Rende, CS, Italy. |
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Abstract: | This study demonstrates how the potentiating effects of E2 on insulin signaling in ER-positive breast cancer cells are consequent to an enhanced IRS-1 expression [corrected]. It induces an increase of both PI-3K/AKT and ERK1/2 activities. A direct action of E2 in the regulating mouse IRS-1 gene is also investigated in both Chinese hamster ovary and MCF-7 cells that are transfected with mouse IRS-1 regulatory sequences. The authors have reported, for the first time, how E2 induction of IRS-1 mRNA was correlated with a direct positive regulatory role of E2 on the IRS-1 promoter. This effect seems to be not strictly related to the cell type. |
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