鲤亚急性喹乙醇中毒的血液生化指标研究

在饲料中分别以 10 0 0mg/kg、2 0 0 0mg/kg、30 0 0mg/kg的喹乙醇剂量对鲤进行了亚急性毒性试验 ,并对中毒鱼进行了血液生化指标的研究 ,经 6周的试验 ,各组的发病率分别为 35 %、70 %、92 .5 % ;死亡率为 2 7.5 %、5 7.5 %、82 5 %。中毒鱼表现为特征性的“应激性出血综合症” ,且Hb含量与RBC数量减少 ,表现为贫血 ;红细胞SOD酶活性降低 ;血清AST、ALT活性升高 ,血清K+ 浓度升高 ,Na+ 浓度降低 ,表现为高血钾和低血钠症。试验组血液生化指标的变化与对照组间存在着显著 (P <0 .0 5 )或极显著的差异 (P <0 .0 1)。

STUDIES ON HAEMATOLOGICAL CHANGES IN COMMON CARP BY SUBACUTE TOXICITY TEST OF OLAQUINDOX

The haematological changes had been studied in common carp (Cyprinus carpio)by Subacute toxicity test of olaquindox. The test was conducted for 6 weeks,with the doses of 1000mg/kg?2000mg/kg?3000mg/kg feed respectively.The morbidity and mortality were 35%?70%?92.5% and 27.5%?57.5%?82.5%,respectively.The clinic symptom of the polisoned fish was characterized by "the stress hemorrhage syndrome."The haematological changes in the poisoned fish showed that the Hb concentration?the RBCnumbers?the red blood cell SOD activity and the serum sodium level dropped;the serum AST?ALT activity and the serum potassium level raised.These haematological changes of the experimental groups were different significangly from the control group.