Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease |
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| Authors: | Lodewijk de Groot Helmy Hinkema Johanna Westra Andries J Smit Cees GM Kallenberg Marc Bijl Marcel D Posthumus |
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| Affiliation: | (1) Department of Rheumatology and Clinical Immunology, University Medical Centre, University of Groningen, Groningen, The Netherlands;(2) Department of Vascular Disease, University Medical Centre, University of Groningen, Groningen, The Netherlands |
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| Abstract: | Introduction Advanced glycation end products (AGEs) are produced and can accumulate during chronic inflammation, as might be present in patients with rheumatoid arthritis (RA). AGEs are involved in the development of cardiovascular disease. The aim of this study is to evaluate whether AGEs are increased in patients with long-standing RA and whether AGE accumulation is related to disease activity, disease severity and measures of (premature) atherosclerosis, such as endothelial activation, endothelial dysfunction and intima media thickness (IMT). |
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| Keywords: | rheumatoid arthritis endothelial cell activation endothelial dysfunction intima media thickness advanced glycation end products atherosclerosis |
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