Increased serum copper and decreased serum zinc levels in children with iron deficiency anemia |
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Authors: | Aydin Ece Bekir Sami Uyamik Akin I?can Pelin Ertan M Ramazan Yi?itolu |
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Institution: | (1) Department of Pediatrics, Celai Bayar University, Faculty of Medicine, Manisa, Turkey;(2) Department of Biochemistry, Celai Bayar University, Faculty of Medicine, Manisa, Turkey |
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Abstract: | In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged
1–14 yr and 64 healthy children as controls aged 1–14 yr were included the study. Serum copper levels were higher in children
with IDA (189 ± 49 (Μg/dL) than those of controls (163 ± 37 Μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 Μg/dL) than those of control subjects (135 ± 56 Μg/dL)
(p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum
copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels
were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum
zinc level in patients.
It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment
should be initiated with zinc. |
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Keywords: | Iron deficiency anemia copper zinc |
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