The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes |
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Authors: | D R Littman Y Thomas P J Maddon L Chess R Axel |
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Institution: | 1. Howard Hughes Medical Institute Columbia University New York, New York 10032 USA;2. Department of Medicine College of Physicians and Surgeons Columbia University New York, New York 10032 USA;3. Department of Biochemistry College of Physicians and Surgeons Columbia University New York, New York 10032 USA |
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Abstract: | The T cell surface glycoproteins T4 and T8 are thought to mediate efficient cell-cell interactions in the immune system and in this way may be responsible for the appropriate targeting of subpopulations of T cells. We have used gene transfer combined with subtractive hybridization to isolate both cDNA and functional genomic clones encoding the T8 protein. The sequence of the cDNA reveals that T8 is a transmembrane protein with an N-terminal domain which shares significant homology to immunoglobulin variable region light chains. This immunoglobulin-like structure is likely to be important in the function of T8 during differentiation and in the course of the immune response. |
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