Recombinational DNA repair: the ignored repair systems |
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| Authors: | Smith Kendric C |
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| Institution: | Emeritus Professor of Radiation Oncology (Radiation Biology), Stanford University School of Medicine, 927 Mears Ct., Stanford, CA 94305-1041, USA. kendric@stanford.edu |
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| Abstract: | The recent finding of a role for the recA gene in DNA replication restart does not negate previous data showing the existence of recA-dependent recombinational DNA repair, which occurs when there are two DNA duplexes present, as in the case for recA-dependent excision repair, for postreplication repair (i.e., the repair of DNA daughter-strand gaps), and for the repair of DNA double-strand breaks. Recombinational DNA repair is critical for the survival of damaged cells. |
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