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Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21. |
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| Authors: | S A Smith D F Easton D Ford J Peto K Anderson D Averill M Stratton M Ponder C Pye B A Ponder |
| Abstract: | In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250. |
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