Microcirculation, hemodynamics and blood rheology in peritonitis during plasmapheresis

By means of biomicroscopy, electrophysiological and hemorheological techniques effect of plasmapheresis with use of various plasma -substituting solutions and their combination on microcirculation, hemodynamics and rheology of blood at peritonitis has been studied in the experiment on 329 white non-inbred rats and on 50 mature dogs. Three periods of disturbances in hemomicrocirculation of the small intestine mesentery at peritonitis have been revealed: I (3-6h)--a relative well-being and compensatory reactions in the system of hemomicrocirculation; II (9-15h)--development of disturbances in the aggregate state of blood; III (18-24h)--pronounced disturbances in hemomicrocirculation. Plasmapheresis at peritonitis facilitates: to better functioning of the microcirculatory system, namely, a sharp increasing of the blood flow rate, joining into the blood flow of capillaries that did not function previously and increasing functional capacity of the capillary bed; decreasing blood viscosity and aggregation of erythrocytes. Plasmapheresis applied at peritonitis produces a favourable effect to hemodynamics, evident as an increasing minute and stroke volume of the blood flow, cardiac index, the left ventricle activity and decrease in peripheral vascular resistance.