Statistical analysis of family data on complex disorders in man |
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| Authors: | Partha P. Majumder Swapan K. Nath |
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| Affiliation: | 1. Anthropometry & Human Genetics Unit, Indian Statistical Institute, 700 035, Calcutta, India
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| Abstract: | A genetic model is discussed for recessively inherited disorders that do not follow a single-locus Mendelian pattern of inheritance. Further complexity arising from variable age of onset is also discussed. Methods of statistical analysis of family data using the likelihood principle are described for such complex disorders. The methods are exemplified using data on families of prelingual deafness and vitiligo. |
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