ON THE UPTAKE OF INOSITOL BY RAT BRAIN SYNAPTOSOMES |
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| Authors: | Anna Warfield Shing Mei Hwang Stanton Segal |
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| Institution: | Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, and the Departments of Pediatrics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, U.S.A. |
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| Abstract: | The uptake of inositol by rat brain synaptosomes occurs via an unsaturable process that even at substrate concentrations as low as 1 μM is unable to achieve a concentration gradient indicative of active transport. Dinitrophenol, ouabain and cytochalasin B did not affect uptake of the cyclitol. The data indicate that inositol uptake by rat synaptosomes occurs by diffusion or by a system with an affinity so low it is difficult to discern. The low capacity, saturable inositol uptake system observed in rabbit brain slices may reflect a species difference or uptake by elements of the slice other than neuronal membranes. |
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