Truncated Bcl-2, a potential pre-metastatic marker in prostate cancer |
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| Authors: | Huang Jen-Ming Lin Tsen-Yin Chang Donald Lin Shi-Lung Ying Shao-Yao |
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| Institution: | Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, BMT-401, 1333 San Pablo Street, Los Angeles, CA 90033, USA. |
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| Abstract: | A novel truncated form of Bcl-2, termed Bcl-2psi, was discovered in invasive prostate cancer cells, using laser capture microdissection, RNA-polymerase cycling reaction, and microarray analysis. The expression of Bcl-2psi increased prior to metastasis in higher-grade prostate cancer. The immunoreactive Bcl-2psi was specifically identified in higher-grade prostate cancer cells. These findings suggest that Bcl-2psi may be a potential pre-metastatic marker for detection, diagnosis, and therapy during the initiation of metastasis in prostate cancer. |
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| Keywords: | Prostate cancer Bcl-2 Bcl-2ψ RNA-PCR Microarray Apoptosis Laser capture microdissection Metastasis Androgen-independent Invasive prostate cancer cells In situ prostate cancer |
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