Tracing the pathway of spindle assembly checkpoint signaling. |
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| Authors: | E S Gillett P K Sorger |
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| Affiliation: | Massachusetts Institute of Technology, Dept of Biology, Cambridge 02139, USA. |
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| Abstract: | Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1. |
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