Innate immunity: regulation of caspases by IAP-dependent ubiquitylation |
| |
Authors: | Falschlehner Christina Boutros Michael |
| |
Institution: | German Cancer Research Center, Division of Signaling and Functional Genomic and Heidelberg University, Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Germany. |
| |
Abstract: | Caspases are widely known as initiators and executioners of cell death. Full activation of caspases leading to cleavage of many cellular substrates was long considered to be a point-of-no-return in the apoptosis pathway. However, it also has been known that activated caspases do not always have the ability to kill, but instead initiate non-apoptotic processes such as cell differentiation or activation of innate immune responses. In this issue of The EMBO Journal, Meinander et al (2012) explore the contribution of polyubiquitination of Dredd, a known initiator caspase, to the activation of innate immunity. The authors show that infection with gram-negative bacteria leads to DIAP2-dependent ubiquitylation of Dredd which in turn is required for processing of Relish (Rel) and expression of antimicrobial peptide (AMP) genes that are indispensable for fighting the infection. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|