Cyclic AMP-dependent phosphorylation, Ca2+ and calmodulin: possible influences on acyltransferases and pyruvate dehydrogenase activities of rat mammary gland |
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| Authors: | H M Valivullah T W Keenan |
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| Affiliation: | 1. Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;2. Department of Thoracic Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, China;3. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;1. Shi-changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, PR China;2. State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China;1. Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China;2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;3. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China;1. College of Materials and Chemical Engineering, Hubei Provincial Collaborative Innovation Center for New Energy Microgrid, China Three Gorges University, 8 Daxue Road, Yichang, Hubei, 443002 China;2. School of Materials Science and Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, Hubei, 430074 China;3. Department of Physics, Sam Houston State University, Huntsville, TX, 77341 USA |
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| Abstract: | Specific activities of diacylglycerol acyltransferase, glycerol 3-phosphate acyltransferase and pyruvate dehydrogenase were studied in virgin, pregnant, lactating and involuting rat mammary glands. An inverse relationship was evident between cAMP binding to protein kinase(s) and the activities of the above enzymes in lactating rat mammary glands. Results suggested that free Ca2+ concentration may also contribute to control of the activity of pyruvate dehydrogenase in these glands. However, no consistent change was observed between the activities of these enzymes and cAMP binding in young, pregnant and involuting rat mammary glands. Calmodulin levels paralleled bound Ca2+ except in lactating rats. Almost all parameters studied peaked on day 8 of lactation. |
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