Concise synthesis and antiviral activity of novel unsaturated acyclic pyrimidine nucleosides |
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Authors: | Oh Chang-Hyun Baek Tae-Rim Hong Joon Hee |
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Institution: | Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea. |
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Abstract: | Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with pyrimidine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds 15-22 were evaluated for their antiviral activity against various viruses such as HIV, HSV-1, HSV-2, and HCMV. |
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