Different effects of chlorpromazine on bleomycin-and epirubicin induced cytotoxicity

The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was testedin vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.